Ruberto Lab @ FSU parasitology, omics, drug discovery

Research

All

2026

Unlocking the potential of ommatins as sustainable photosensitizers for photodynamic therapy
Unlocking the potential of ommatins as sustainable photosensitizers for photodynamic therapy
Arif Hussain, Anthony A. Ruberto, Harsh Bhatia, Steven P. Maher, Yifan Quan, …, Hannah Sayre, Robert G. Griffin, Dennis E. Kyle, Prakash T. Parvatkar, Roman Manetsch
Bioorganic & Medicinal Chemistry Letters  ·  01 Nov 2026  ·  doi:10.1016/j.bmcl.2026.130737
Memory regulatory T cells reprogram into protective TFH cell-like effectors in recurrent malaria
Memory regulatory T cells reprogram into protective TFH cell-like effectors in recurrent malaria
Nana Appiah Essel Charles-Chess, Anthony A. Ruberto, Carson Bowers, Clyde Schmidt-Silva, Nyamekye Obeng-Adjei, …, Alex Rosenberg, Boubacar Traore, Kimberly D. Klonowski, Peter D. Crompton, Samarchith P. Kurup
Nature Immunology  ·  01 Aug 2026  ·  doi:doi.org/10.1038/s41590-026-02537-z
MaRNAV-1, an intracellular virus of i Plasmodium vivax i , is associated with increased parasite transmission and altered host immune response
MaRNAV-1, an intracellular virus of Plasmodium vivax , is associated with increased parasite transmission and altered host immune response
Dynang Seng, Katie Ko, Agnes Orban, Sokleap Heng, Lionel Brice Feufack-Donfack, …, Mary E Petrone, Tineke Cantaert, Sebastian Baumgarten, David Serre, Jean Popovici
openRxiv  ·  25 Mar 2026  ·  doi:10.64898/2026.03.22.713337

2025

A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites
A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites
Steven P Maher, Malina A Bakowski, Amélie Vantaux, Erika L Flannery, Chiara Andolina, …, Chester Joyner, François H Nosten, Benoît Witkowski, Karine G Le Roch, Dennis E Kyle
eLife  ·  30 Sep 2025  ·  doi:10.7554/elife.98221
Discovery and optimization of a novel carboxamide scaffold with selective antimalarial activity
Discovery and optimization of a novel carboxamide scaffold with selective antimalarial activity
Alicia Wagner, Roger Trombley, Maris Podgurski, Anthony A. Ruberto, Meng Cui, …, Sarah Lee Mai, Franco Lombardo, Steven P. Maher, Dennis E. Kyle, Roman Manetsch
European Journal of Medicinal Chemistry  ·  01 Jul 2025  ·  doi:10.1016/j.ejmech.2025.117572
The i Toxoplasma gondii i homolog of ATPase inhibitory factor 1 is critical for mitochondrial cristae maintenance and stress response
The Toxoplasma gondii homolog of ATPase inhibitory factor 1 is critical for mitochondrial cristae maintenance and stress response
Madelaine M. Usey, Anthony A. Ruberto, Kaelynn V. Parker, Diego Huet
Molecular Biology of the Cell  ·  01 Jan 2025  ·  doi:10.1091/mbc.e24-08-0344

2024

Screening the Global Health Priority Box against Plasmodium berghei liver stage parasites using an inexpensive luciferase detection protocol
Screening the Global Health Priority Box against Plasmodium berghei liver stage parasites using an inexpensive luciferase detection protocol
Gia-Bao Nguyen, Caitlin A. Cooper, Olivia McWhorter, Ritu Sharma, Anne Elliot, Anthony Ruberto, Rafael Freitas, Ashutosh K. Pathak, Dennis E. Kyle, Steven P. Maher
Malaria Journal  ·  23 Nov 2024  ·  doi:10.1186/s12936-024-05155-y
Unraveling the intricacies of host-pathogen interaction through single-cell genomics
Unraveling the intricacies of host-pathogen interaction through single-cell genomics
Emanuele Gioacchino, Koen Vandelannoote, Anthony A. Ruberto, Jean Popovici, Tineke Cantaert
Microbes and Infection  ·  01 Sep 2024  ·  doi:10.1016/j.micinf.2024.105313

2023

Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae
Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae
Robert A. Shepherd, Cody E. Earp, Kristof B. Cank, Huzefa A. Raja, Joanna Burdette, …, Sarah Lee Mai, Blaise A. Darveaux, Dennis E. Kyle, Cedric J. Pearce, Nicholas H. Oberlies
The Journal of Antibiotics  ·  20 Sep 2023  ·  doi:10.1038/s41429-023-00655-6

2022

Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets
Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets
Anthony A. Ruberto, Steven P. Maher, Amélie Vantaux, Chester J. Joyner, Caitlin Bourke, Balu Balan, Aaron Jex, Ivo Mueller, Benoit Witkowski, Dennis E. Kyle
Frontiers in Cellular and Infection Microbiology  ·  25 Aug 2022  ·  doi:10.3389/fcimb.2022.986314
Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures
Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures
Anthony A. Ruberto, Caitlin Bourke, Amélie Vantaux, Steven P. Maher, Aaron Jex, Benoit Witkowski, Georges Snounou, Ivo Mueller
PLOS Neglected Tropical Diseases  ·  04 Aug 2022  ·  doi:10.1371/journal.pntd.0010633

2021

KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
Anthony A Ruberto, Aline Gréchez-Cassiau, Sophie Guérin, Luc Martin, Johana S Revel, Mohamed Mehiri, Malayannan Subramaniam, Franck Delaunay, Michèle Teboul
eLife  ·  17 Aug 2021  ·  doi:10.7554/elife.65574
Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites
Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites
Anthony A. Ruberto, Caitlin Bourke, Nicolas Merienne, Thomas Obadia, Rogerio Amino, Ivo Mueller
Scientific Reports  ·  22 Feb 2021  ·  doi:10.1038/s41598-021-82914-w

2020

MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice
MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice
Pierre S. Leclère, Déborah Rousseau, Stéphanie Patouraux, Sophie Guérin, Stéphanie Bonnafous, …, Malayannan Subramaniam, Albert Tran, Franck Delaunay, Philippe Gual, Michèle Teboul
Scientific Reports  ·  22 Jul 2020  ·  doi:10.1038/s41598-020-69085-w

2019

Temperature and serine phosphorylation regulate glycerol-3-phosphate dehydrogenase in skeletal muscle of hibernating Richardson s ground squirrels
Temperature and serine phosphorylation regulate glycerol-3-phosphate dehydrogenase in skeletal muscle of hibernating Richardson’s ground squirrels
Anthony A. Ruberto, Samantha M. Logan, Kenneth B. Storey
Biochemistry and Cell Biology  ·  01 Apr 2019  ·  doi:10.1139/bcb-2018-0198

2016

Purification and properties of glycerol-3-phosphate dehydrogenase from the liver of the hibernating ground squirrel, Urocitellus richardsonii
Purification and properties of glycerol-3-phosphate dehydrogenase from the liver of the hibernating ground squirrel, Urocitellus richardsonii
Anthony A. Ruberto, Christine L. Childers, Kenneth B. Storey
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology  ·  01 Dec 2016  ·  doi:10.1016/j.cbpb.2016.08.001

The role of the circadian transcription factor KLF10 in liver physiology
The role of the circadian transcription factor KLF10 in liver physiology
Anthony Ruberto
Agence Bibliographique de l'Enseignement Supérieur  ·  [no date info]  ·  doi:10.70675/cb3492c2z5778z48e3za7d7zf17279fd718b