Research

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Highlighted

Open collaborative writing with Manubot

Daniel S. Himmelstein, Vincent Rubinetti, David R. Slochower, Dongbo Hu, Venkat S. Malladi, Casey S. Greene, Anthony Gitter

PLOS Computational Biology  ·  04 Dec 2020  ·  doi:10.1371/journal.pcbi.1007128

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Manubot

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2026

Unlocking the potential of ommatins as sustainable photosensitizers for photodynamic therapy

Arif Hussain, Anthony A. Ruberto, Harsh Bhatia, Steven P. Maher, Yifan Quan, …, Hannah Sayre, Robert G. Griffin, Dennis E. Kyle, Prakash T. Parvatkar, Roman Manetsch

Bioorganic & Medicinal Chemistry Letters  ·  01 Nov 2026  ·  doi:10.1016/j.bmcl.2026.130737

Memory regulatory T cells reprogram into protective TFH cell-like effectors in recurrent malaria

Nana Appiah Essel Charles-Chess, Anthony A. Ruberto, Carson Bowers, Clyde Schmidt-Silva, Nyamekye Obeng-Adjei, …, Alex Rosenberg, Boubacar Traore, Kimberly D. Klonowski, Peter D. Crompton, Samarchith P. Kurup

Nature Immunology  ·  01 Aug 2026  ·  doi:doi.org/10.1038/s41590-026-02537-z

MaRNAV-1, an intracellular virus of Plasmodium vivax , is associated with increased parasite transmission and altered host immune response

Dynang Seng, Katie Ko, Agnes Orban, Sokleap Heng, Lionel Brice Feufack-Donfack, …, Mary E Petrone, Tineke Cantaert, Sebastian Baumgarten, David Serre, Jean Popovici

openRxiv  ·  25 Mar 2026  ·  doi:10.64898/2026.03.22.713337

2025

A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites

Steven P Maher, Malina A Bakowski, Amélie Vantaux, Erika L Flannery, Chiara Andolina, …, Chester Joyner, François H Nosten, Benoît Witkowski, Karine G Le Roch, Dennis E Kyle

eLife  ·  30 Sep 2025  ·  doi:10.7554/elife.98221

Discovery and optimization of a novel carboxamide scaffold with selective antimalarial activity

Alicia Wagner, Roger Trombley, Maris Podgurski, Anthony A. Ruberto, Meng Cui, …, Sarah Lee Mai, Franco Lombardo, Steven P. Maher, Dennis E. Kyle, Roman Manetsch

European Journal of Medicinal Chemistry  ·  01 Jul 2025  ·  doi:10.1016/j.ejmech.2025.117572

The Toxoplasma gondii homolog of ATPase inhibitory factor 1 is critical for mitochondrial cristae maintenance and stress response

Madelaine M. Usey, Anthony A. Ruberto, Kaelynn V. Parker, Diego Huet

Molecular Biology of the Cell  ·  01 Jan 2025  ·  doi:10.1091/mbc.e24-08-0344

2024

Discovery and Optimization of a Novel Carboxamide Scaffold with Selective Antimalarial Activity

Alicia Wagner, Roger Trombley, Maris Podgurski, Anthony A. Ruberto, Meng Cui, …, Sarah Lee Mai, Franco Lombardo, Steven P. Maher, Dennis E. Kyle, Roman Manetsch

American Chemical Society (ACS)  ·  20 Dec 2024  ·  doi:10.26434/chemrxiv-2024-h5zgs

Screening the Global Health Priority Box against Plasmodium berghei liver stage parasites using an inexpensive luciferase detection protocol

Gia-Bao Nguyen, Caitlin A. Cooper, Olivia McWhorter, Ritu Sharma, Anne Elliot, Anthony Ruberto, Rafael Freitas, Ashutosh K. Pathak, Dennis E. Kyle, Steven P. Maher

Malaria Journal  ·  23 Nov 2024  ·  doi:10.1186/s12936-024-05155-y

Unraveling the intricacies of host-pathogen interaction through single-cell genomics

Emanuele Gioacchino, Koen Vandelannoote, Anthony A. Ruberto, Jean Popovici, Tineke Cantaert

Microbes and Infection  ·  01 Sep 2024  ·  doi:10.1016/j.micinf.2024.105313

2023

Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae

Robert A. Shepherd, Cody E. Earp, Kristof B. Cank, Huzefa A. Raja, Joanna Burdette, …, Sarah Lee Mai, Blaise A. Darveaux, Dennis E. Kyle, Cedric J. Pearce, Nicholas H. Oberlies

The Journal of Antibiotics  ·  20 Sep 2023  ·  doi:10.1038/s41429-023-00655-6

2022

Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets

Anthony A. Ruberto, Steven P. Maher, Amélie Vantaux, Chester J. Joyner, Caitlin Bourke, Balu Balan, Aaron Jex, Ivo Mueller, Benoit Witkowski, Dennis E. Kyle

Frontiers in Cellular and Infection Microbiology  ·  25 Aug 2022  ·  doi:10.3389/fcimb.2022.986314

Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures

Anthony A. Ruberto, Caitlin Bourke, Amélie Vantaux, Steven P. Maher, Aaron Jex, Benoit Witkowski, Georges Snounou, Ivo Mueller

PLOS Neglected Tropical Diseases  ·  04 Aug 2022  ·  doi:10.1371/journal.pntd.0010633

2021

KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

Anthony A Ruberto, Aline Gréchez-Cassiau, Sophie Guérin, Luc Martin, Johana S Revel, Mohamed Mehiri, Malayannan Subramaniam, Franck Delaunay, Michèle Teboul

eLife  ·  17 Aug 2021  ·  doi:10.7554/elife.65574

Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites

Anthony A. Ruberto, Caitlin Bourke, Nicolas Merienne, Thomas Obadia, Rogerio Amino, Ivo Mueller

Scientific Reports  ·  22 Feb 2021  ·  doi:10.1038/s41598-021-82914-w

2020

Open collaborative writing with Manubot

Daniel S. Himmelstein, Vincent Rubinetti, David R. Slochower, Dongbo Hu, Venkat S. Malladi, Casey S. Greene, Anthony Gitter

PLOS Computational Biology  ·  04 Dec 2020  ·  doi:10.1371/journal.pcbi.1007128

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.

Manubot

Manuscript Source

Website

open-science collaboration

MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice

Pierre S. Leclère, Déborah Rousseau, Stéphanie Patouraux, Sophie Guérin, Stéphanie Bonnafous, …, Malayannan Subramaniam, Albert Tran, Franck Delaunay, Philippe Gual, Michèle Teboul

Scientific Reports  ·  22 Jul 2020  ·  doi:10.1038/s41598-020-69085-w

Constructing knowledge graphs and their biomedical applications

David N. Nicholson, Casey S. Greene

Computational and Structural Biotechnology Journal  ·  01 Jan 2020  ·  doi:10.1016/j.csbj.2020.05.017

2019

Temperature and serine phosphorylation regulate glycerol-3-phosphate dehydrogenase in skeletal muscle of hibernating Richardson’s ground squirrels

Anthony A. Ruberto, Samantha M. Logan, Kenneth B. Storey

Biochemistry and Cell Biology  ·  01 Apr 2019  ·  doi:10.1139/bcb-2018-0198

2018

Sci-Hub provides access to nearly all scholarly literature

Daniel S Himmelstein, Ariel Rodriguez Romero, Jacob G Levernier, Thomas Anthony Munro, Stephen Reid McLaughlin, Bastian Greshake Tzovaras, Casey S Greene

eLife  ·  01 Mar 2018  ·  doi:10.7554/eLife.32822

2016

Purification and properties of glycerol-3-phosphate dehydrogenase from the liver of the hibernating ground squirrel, Urocitellus richardsonii

Anthony A. Ruberto, Christine L. Childers, Kenneth B. Storey

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology  ·  01 Dec 2016  ·  doi:10.1016/j.cbpb.2016.08.001

The role of the circadian transcription factor KLF10 in liver physiology

Anthony Ruberto

Agence Bibliographique de l'Enseignement Supérieur  ·  [no date info]  ·  doi:10.70675/cb3492c2z5778z48e3za7d7zf17279fd718b